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Postdoctoral positions
A key aspect of our postdoctoral program is that fellows publish their research in peer-reviewed journals. Some recent publications, with our postdoctoral fellows as the lead authors, are highlighted here; this list will be updated regularly.
Follow this link for a more comprehensive list of NIBR publications
Publications
The mevalonate pathway of Staphylococcus aureus.
Balibar CJ, Shen X, Tao J.
J Bacteriol. 2009 Feb;191(3):851-61.
Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.
Berdichevsky A, Guarente L, Bose A.
J Biol Chem. 2010 Jul 9;285(28):21581-9.
Bone morphogenetic protein receptor-II regulates pulmonary artery endothelial cell barrier function.
Burton VJ, Ciuclan LI, Holmes AM, Rodman DM, Walker C, Budd DC.
Blood. 2011 Jan 6;117(1):333-41.
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.
Chau MD, Gao J, Yang Q, Wu Z, Gromada J.
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8.
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints.
Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu G, Li E, Chen T.
Nature. 2009 Sep 17;461(7262):415-8.
Ensemble docking into multiple crystallographically derived protein structures: an evaluation based on the statistical analysis of enrichments.
Craig IR, Essex JW, Spiegel K.
J Chem Inf Model. 2010 Apr 26;50(4):511-24.
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.
Golks, A, Tran, TT, Goetschy, JF, and Guerini, D.
EMBO J. 2007 Oct 17;26(20):4368-79.
Automated NMR Resonance Assignment of Large Proteins for Protein-Ligand Interaction Studies.
Gossert AD, Hiller S, Fernández C.
J Am Chem Soc. 2010 Dec 16. [Epub ahead of print]
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.
Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M.
Nat Med. 2010 Dec;16(12):1429-33.
The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.
Jagani Z, Wiederschain D, Loo A, He D, Mosher R, Fordjour P, Monahan J, Morrissey M, Yao YM, Lengauer C, Warmuth M, Sellers WR, Dorsch M.
Cancer Res. 2010 Jul 1;70(13):5528-38.
Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype.
Jiang J, Zhang Y, Chuai S, Wang Z, Zheng D, Xu F, Zhang Y, Li C, Liang Y, Chen Z.
Oncogene. 2011 Jul 11. doi: 10.1038/onc.2011.282. [Epub ahead of print]
IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.
Koziczak-Holbro M, Joyce C, Glück A, Kinzel B, Müller M, Tschopp C, Mathison JC, Davis CN, Gram H.
J Biol Chem. 2007 May 4;282(18):13552-60.
Three Descriptor Model Sets a High Standard for the CSAR-NRC HiQ Benchmark.
Kramer C, Gedeck P.
J Chem Inf Model. 2011 Jun 27. [Epub ahead of print]
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis.
Kramer I, Halleux C, Keller H, Pegurri M, Gooi JH, Weber PB, Feng JQ, Bonewald LF, Kneissel M.
Mol Cell Biol. 2010 Jun;30(12):3071-85.
Comparison of multivariate data analysis strategies for high-content screening.
Kümmel A, Selzer P, Beibel M, Gubler H, Parker CN, Gabriel D.
J Biomol Screen. 2011 Mar;16(3):338-47.
Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo.
Kurash, JK, Lei, H, Shen, Q, Marston, WL, Granda, BW, Fan, H, Wall, D, Li, E, and Gaudet, F.
Mol. Cell. 2008 Feb 15;29(3):392-400.
KMT1E Mediated H3K9 Methylation is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation.
Lohmann F, Loureiro J, Su H, Fang Q, Lei H, Lewis T, Yang Y, Labow M, Li E, Chen T, Kadam S.
Stem Cells. 2010 Feb;28(2):201-12
Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
Martin LJ, Marzinzik AL, Ley SV, Baxendale IR.
Organic Letters, 2011, 13 (2), pp 320-323.
Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules.
Möker N, Dean CR, Tao J.
J Bacteriol. 2010 Apr;192(7):1946-55.
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Mullershausen F, Zecri F, Cetin C, Billich A, Guerini D, Seuwen K.
Nat Chem Biol. 2009 Jun;5(6):428-34.
Th17 Cells, Not IL-17+ gamma delta T Cells, Drive Arthritic Bone Destruction in Mice and Humans.
Pöllinger B, Junt T, Metzler B, Walker UA, Tyndall A, Allard C, Bay S, Keller R, Raulf F, Di Padova F, O'Reilly T, Horwood NJ, Patel DD, Littlewood-Evans A.
J Immunol. 2011 Feb 15;186(4):2602-12.
The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity.
Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJ, Rot A.
Nat Immunol. 2009 Jan;10(1):101-8.
Human Cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection.
Reeves M, Woodhall D, Compton T, Sinclair J.
J Virol. 2010 Jul;84(14):7185-94.
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.
Rubic, T. Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, Schwarzler C, Junt T, Voshol H, Meingassner JG, Mao X, Werner G, Rot A, Carballido JM.
Nat Immunol. 2008 Nov;9(11):1261-9.
Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts.
Ruiz PA, Jarai G.
J Biol Chem. 2011 Apr 15;286(15):12912-23.
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.
Schneider, MA, Meingassner, JG, Lipp, M, Moore, HD, Rot, A.
J Exp Med. 2007 Apr 16;204(4):735-45.
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.
Sukuru SC, Nigsch F, Quancard J, Renatus M, Chopra R, Brooijmans N, Mikhailov D, Deng Z, Cornett A, Jenkins JL, Hommel U, Davies JW, Glick M.
Protein Sci. 2010 Nov;19(11):2096-109.
Wnt3a Induced Mesoderm Formation and Cardiomyogenesis in Human Embryonic Stem Cells.
Tran TH, Wang X, Browne C, Zhang Y, Schinke M, Izumo S, Burcin M.
Stem Cells. 2009 Aug;27(8):1869-78.
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation.
Wang J, Hevi S, Kurash JK, Lei H, Gay F, Bajko J, Su H, Sun W, Chang H, Xu G, Gaudet F, Li E, Chen T.
Nat Genet. 2009 Jan;41(1):125-9.
PTEN-deficient cancers are dependent on PIK3CB.
Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F,Yao YM, and Lengauer C.
Proc. Natl. Acad. Sci. USA, 105: 13057 — 62.
PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers.
Wee S, Jagani Z, Xiang KX, Loo A, Dorsch M, Yao YM, Sellers WR, Lengauer C, Stegmeier F.
Cancer Res. 2009 May 15;69(10):4286-93.
Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis.
Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang, YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, and Benson JD.
Mol Cell Biol. 2007 Jul;27(13):4968-79.
Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA., Labow M, Jenkins JL, Mitchison TJ, and Feng Y.
Nat Chem Biol. 2008 Jan;4(1):18-9.
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F.
Nat Cell Biol. 2011 May;13(5):623-9.
Continuous flow coupling and decarboxylation reactions promoted by copper tubing.
Zhang Y, Jamison TF, Patel S, Mainolfi N.
Org Lett. 2011 Jan 21;13(2):280-3.





