• A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymerase.
  Niyomrattanakit P, Abas SN, Lim CC, Beer D, Shi PY, Chen YL. Novartis Institute for Tropical Diseases, Chromos, Singapore. J Biomol Screen. 2011 Feb;16(2):201-10. Epub 2011 Jan 10.
• A single amino acid in nonstructural NS4B protein confers virulence to Dengue virus in AG129 mice through enhancement of viral RNA synthesis.
  Grant D, Tan GK, Qing M, Ng JK, Yip A, Zou G, Xie X, Yuan Z, Schreiber MJ, Schul W, Shi PY, Alonso S. - J Virol. 2011August.
• Development and characterization of a stable luciferase dengue virus for high-throughput screening.
  Zou G, Xu HY, Qing M, Wang QY, Shi PY. Antiviral Res. 2011 Jul;91(1):11-9. Epub 2011 May 7.
• Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis.
  Wang QY, Bushell S, Qing M, Xu HY, Bonavia A, Nunes S, Zhou J, Poh MK, Florez de Sessions P, Niyomrattanakit P, Dong H, Hoffmaster K, Goh A, Nilar S, Schul W, Jones S, Kramer L, Compton T, Shi PY. J Virol. 2011 Jul;85(13):6548-56. Epub 2011 Apr 20.
• The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry.
  Lin SR, Zou G, Hsieh SC, Qing M, Tsai WY, Shi PY, Wang WK. J Virol. 2011 May;85(10):5159-71. Epub 2011 Mar 2.
• Functional analysis of two cavities in flavivirus NS5 polymerase.
  Zou G, Chen YL, Dong H, Lim CC, Yap LJ, Yau YH, Shochat SG, Lescar J, Shi PY. J Biol Chem. 2011 Apr 22;286(16):14362-72. Epub 2011 Feb 23.
• Small molecule inhibitors that selectively block dengue virus methyltransferase.
  Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY. J Biol Chem. 2011 Feb 25;286(8):6233-40. Epub 2010 Dec 8.
• The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry.
  Hsieh SC, Zou G, Tsai WY, Qing M, Chang GJ, Shi PY, Wang WK. Virology. 2011 Feb 5;410(1):170-80. Epub 2010 Dec 3.
• Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
  Heng Y, Seah PG, Siew JY, Tay HC, Singhal A, Mathys V, Kiass M, Bifani P, Dartois V, Hervé M. Novartis Institute for Tropical Diseases, #05-01 Chromos, 10 Biopolis road, Singapore 138670, Singapore. Tuberculosis (Edinb). 2011 May 31
• Experimental tuberculosis in the Wistar rat: A model for Protective Immunity and control of infection.
  Singhal A, Aliouat EM, Hervé M, Mathys V, Kiass M, Creusy C, Delaire B, Tsenova L, Fleurisse L, Bertout J, Camacho L, Foo D, Tay HC, Siew JY, Boukhouchi W, Romano M, Mathema B, Dartois V, Kaplan G, Bifani P. Novartis Institute for Tropical Diseases, Singapore. PLoS ONE. 2011 Apr 12, 6(4): e18632.
• Structure-based design of small-molecules that selectively inhibit dengue virus methyltransferase.
  Noble CG Novartis Institute for Tropical Diseases, Singapore. Antiviral Research. May2011, 90(2).
• High sensitivity MALDI-MRM-MS Imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions.
  Prideaux B, Dartois V, Staab D, Weiner DM, Goh A, Via LE, Barry CE, Stoeckli M. Antiviral Research. May2011, 90(2).
• The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.
  Schmitt EK, Riwanto M, Sambandamurthy V, Roggo S, Miault C, Zwingelstein C, Krastel P, Noble C, Beer D, Rao SP, Au M, Niyomrattanakit P, Lim V, Zheng J, Jeffery D, Pethe K, Camacho LR (2011). Angew Chem Int Ed Engl.;50(26):5889-91.
• Drug resistance among tuberculosis patients attending diagnostic and treatment centres in Makassar, Indonesia.
  Massi MN, Wahyuni S, Halik H; Anita, Yusuf I, Leong FJ, Dick T, Phyu S. (2011) (2011) Int J Tuberc Lung Dis. 15(4):489-95.
  
• Book Chapter title "Natural products; new agents against MDR Tuberculosis" Book title "Drug discovery from natural products". Ujjini Manjunatha, Fumiaki Yokokawa, Meera Gurumurthy and Thomas Dick (2011) Publisher: RSC (Royal Society of Chemistry)
• A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis.
  Daniel J. Wilson, Ce Shi, Benjamin P. Duckworth, Joseph M. Muretta, Ujjini Manjunatha, Yuk Y. Sham, David D. Thomas, Courtney C. Aldrich. (2011) Analytical Biochem., (in press).
• 3rd Structure-Activity Relationships of Antitubercular Nitroimidazoles. 3. (3D-QSAR) Pharmacophore -driven exploration of the linker and lipophilic tail of 6-amino PA-824.
  Joseph Cherian, Inhee Choi, Amit Nayyar, Ujjini H. Manjunatha, Tathagata Mukherjee, Helena I. Boshoff, Ramandeep Singh, Young Hwan Ha, Michael Goodwin, Suresh B. Lakshminarayana, Pornwaratt Niyomrattanakit, Jan Jiricek, Sindhu Ravindran, Thomas Dick, Thomas H. Keller, Veronique Dartois, Clifton E. Barry, Journal of Medicinal Chemistry, 2011 (in press).
• Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
  Sae Woong Park, Marcus Klotzsche, Daniel J. Wilson, Helena I. Boshoff, Hyungjin Eoh, Ujjini Manjunatha, Antje Blumenthal, Kyu Rhee, Clifton E. Barry III, Courtney C. Aldrich, Sabine Ehrt, and Dirk Schnappinger Plos One, 2011 (in press)
• A translation inhibitor that suppresses dengue virus in vitro and in vivo.
  Qing-Yin Wang1, Ravinder Reddy Kondreddi1, Xuping Xie1, Ranga Rao1, Shahul Nilar1, Hao Ying Xu1, Min Qing1, David Chang1, Hongping Dong1, Fumiaki Yokokawa1, Suresh B. Lakshminarayana1, Anne Goh1, Wouter Schul1, Laura Kramer2, Thomas H. Keller1, and Pei-Yong Shi1,* 1 Novartis Institute for Tropical Diseases, Singapore, 2 Wadsworth Center, New York State Department of Health, Albany, NY, USA. Antimicrob. Agents Chemother. doi:10.1128/AAC.00620-11. July 2011
• Dengue Drug Discovery.
  Pei-Yong Shi, Zheng Yin, Shahul Nilar and Thomas H. Keller. Third World Diseases Topics in Medicinal Chemistry, 2011, Volume 7, 243-275, DOI: 10.1007/7355_2011_16
• Imidazolopiperazines: Hit to Lead Optimisation of New Antimalarial Agents.
  Wu, T (Wu, Tao)1; Nagle, A (Nagle, Advait)1; Kuhen, K (Kuhen, Kelli)1; Gagaring, K (Gagaring, Kerstin)1; Borboa, R (Borboa, Rachel)1; Francek, C (Francek, Caroline)1; Chen, Z (Chen, Zhong)1; Plouffe, D (Plouffe, David)1; Goh, A (Goh, Anne)3; Lakshminarayana, SB (Lakshminarayana, Suresh B.)3; Wu, J (Wu, Jeanette)3; Ang, HQ (Ang, Hui Qing)3; Zeng, PT (Zeng, Peiting)3; Kang, ML (Kang, Min Low)3; Tan, W (Tan, William)3; Tan, M (Tan, Maria)3; Ye, N (Ye, Nicole)3; Lin, XN (Lin, Xuena)5; Caldwell, C (Caldwell, Christopher)5; Ek, J (Ek, Jared)1; Skolnik, S (Skolnik, Suzanne)5; Liu, FH (Liu, Fenghua)5; Wang, JL (Wang, Jianling)5; Chang, J (Chang, Jonathan)1; Li, C (Li, Chun)1; Hollenbeck, T (Hollenbeck, Thomas)1; Tuntland, T (Tuntland, Tove)1; Isbell, J (Isbell, John)1; Fischli, C (Fischli, Christoph)2,4; Brun, R (Brun, Reto)2,4; Rottmann, M (Rottmann, Matthias)2,4; Dartois, V (Dartois, Veronique)3; Keller, T (Keller, Thomas)3; Diagana, T (Diagana, Thierry)3; Winzeler, E (Winzeler, Elizabeth)1; Glynne, R (Glynne, Richard)1; Tully, DC (Tully, David C.)1; Chatterjee, AK (Chatterjee, Arnab K.)1, Journal of Medicinal Chemistry, 54(14):5116-5130 Jul 28 2011
• T Cell Monitoring of Chemotherapy in Experimental Rat Tuberculosis.
  Foo, DG (Foo, Damian Guang)1; Tay, HC (Tay, Hui Chien)1; Siew, JY (Siew, Jie Yee)1; Singhal, A (Singhal, Amit)1; Camacho, L (Camacho, Luis)1; Bifani, P (Bifani, Pablo)1; Dartois, V (Dartois, Veronique)1; Herve, M (Herve, Maxime)1, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(8): 3677-3683 Aug 2011
• Reagent Precoated Targets for Rapid In-Tissue Derivatization of the Anti-Tuberculosis Drug Isoniazid Followed by MALDI Imaging Mass Spectrometry.
  Manier, ML (Manier, M. Lisa)1; Reyzer, ML (Reyzer, Michelle L.)1; Goh, A (Goh, Anne)2; Dartois, V (Dartois, Veronique)2; Via, LE (Via, Laura E.)3; Barry, CE (Barry, Clifton E., III)3; Caprioli, RM (Caprioli, Richard M.)1,4,5,6, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(8): 1409-1419 Aug 2011
• Anti-infectives: Can cellular screening deliver?
  Keller, TH (Keller, Thomas H.)2; Shi, PY (Shi, Pei-Yong)1; Wang, QY (Wang, Qing-Yin)1, CURRENT OPINION IN CHEMICAL BIOLOGY, 15(4): 529-533 Aug 2011
• Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B.
  Yeung, BKS (Yeung, Bryan K. S.), CURRENT OPINION IN CHEMICAL BIOLOGY, 15(4): 523-528 Aug 2011
• Characterization of early host responses in adults with dengue disease.
  Tolfvenstam, T (Tolfvenstam, Thomas)1,2; Lindblom, A (Lindblom, Anna)1; Schreiber, MJ (Schreiber, Mark J.)3; Ling, L (Ling, Ling)1; Chow, A (Chow, Angelia)4; Ooi, EE (Ooi, Eng Eong)4; Hibberd, ML (Hibberd, Martin L.)1, BMC INFECTIOUS DISEASES, 11, 209 Aug 2 2011

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