Proteomic Chemistry

The work of the Center for Proteomic Chemistry (CPC) lies at the intersection of the chemical and biological universes. CPC’s goal is the systematic study of  the interactions of small chemical molecules with large biological macromolecules, generally proteins.

CPC’s scientific operations are made possible by substantial expertise in assay automation, compound logistics, information technology, and the management and interpretation of vast amounts of experimental data for high-throughput screening.

Drug (hit)-target interactions are studied by biophysical, protein structure, and cheminformatics approaches. Validated hits with the desired properties are passed on to Global Discovery Chemistry (GDC) for optimization.

CPC has two established platforms dedicated to two important target families, kinases and proteases. In addition, there is a group dedicated to natural products research that strives to leverage the molecular diversity of nature for therapeutic purposes.

CPC’s capabilities include high-throughput screening, preclinical safety profiling, protein structure elucidation, natural products discovery, and protease and kinase research.