Speaker: Arthur D. Lander, M.D., Ph.D. Donald Bren Professor of Developmental and Cell Biology Director, Center for Complex Biological Systems University of California, Irvine
Seminar Abstract: The ability of tissues and organs to reach and maintain precisely specified sizes is an astonishing feat of biological engineering, arising not from the cell-autonomous properties of cells, but from feedback interactions within cell collectives. I will discuss the mechanisms currently known to account for growth control; their strengths and limitations; and how they constrain the ways in which escape from control can occur. I will argue that an understanding of such constraints can provide useful new insights into proliferative disorders, including cancer.
Entry instructions: There is no cost to attend the seminar. If you are interested in attending please contact Meghan Spencer. Please check in with security at the Novartis visitor's entrance of 220 Massachusetts Avenue and you will be directed to the location of the seminar.
Speaker | Arthur D. Lander, M.D., Ph.D.
Arthur D. Lander is the Donald Bren Professor of Developmental and Cell Biology at the University of California, Irvine, where he also holds joint appointments in the Departments of Biomedical Engineering and Logic & Philosophy of Science. He serves as director of the Center for Complex Biological Systems (CCBS), one of 13 NIH-supported National Centers for Systems Biology, which promotes interdisciplinary research and training at the interface between biology, mathematics, physics, computer science and engineering. Through his research, which combines both experimental and theoretical approaches, he has contributed to the understanding of biological pattern formation and growth control, focusing on design principles underlying the mechanisms by which biological systems function reliably in the face of real-world disturbances. His work has applications to the understanding of birth defects, the origins and treatment of cancer, and the genetics of complex disease. Dr. Lander received his B.S. degree in Molecular Biophysics and Biochemistry from Yale University, and then earned an M.D. degree and a Ph.D. in neuroscience at the University of California, San Francisco. In addition to founding CCBS, he spearheaded the creation of UCI’s graduate training program in Mathematical, Computational and Systems Biology. Dr. Lander has been the recipient of a David and Lucille Packard Fellowship for Science and Engineering and an NIH-Javits Neuroscience Investigator Award, and is an elected member of the American Society for Clinical Investigation and a fellow of the American Association for the Advancement of Science. He serves on the Science Board of the Santa Fe Institute, and currently chairs the NIH MABS (Modeling and Analysis of Biological Systems) grant review panel. He also holds visiting faculty appointments at the University of Tsukuba (Japan), and National Taiwan University.