Engineering 3D culture models of physiology and disease
17 May 2017 12:00 to 13:00 EDT
220 Mass. Avenue, Cambridge MA - USA
Speaker: Christopher S. Chen, M.D., Ph.D. Founding Director, The Biological Design Center Distinguished Professor of Biomedical Engineering, Boston University Wyss Institute for Biologically Inspired Engineering, Harvard University
Seminar Abstract: In vivo, local tissue structure defines the cellular environment, constraining how cells interact with surrounding extracellular matrix substrates, neighboring cells, soluble growth factors, and physical forces. These “microenvironmental” cues in turn play a central role in regulating the behavior of individual resident cells, such as proliferation, differentiation, migration, and suicide. Here, I will present 3D culture platforms that are able to recapitulate more complex functions of biological tissues, and how we are using them to gain deeper insights into disease and physiology.
Entry instructions: There is no cost to attend the seminar. If you are interested in attending please contact Meghan Spencer. Please check in with security at the Novartis visitor's entrance of 220 Massachusetts Avenue and you will be directed to the location of the seminar.
Speaker | Christopher S. Chen, M.D., Ph.D.
Christopher S. Chen, M.D., Ph.D., is Founding Director of the Biological Design Center, and Professor of Biomedical Engineering at Boston University and the Wyss Institute for Biologically Inspired Engineering at Harvard University. Dr. Chen has been an instrumental figure in the development of engineered cellular microenvironments to understand how cells build tissues. He has used these approaches to demonstrate a role for cell adhesion, shape, and cytoskeletal mechanics in regulating cell proliferation, differentiation, and apoptosis, and patterning tissue architecture. He serves as a member of the American Institute for Medical and Biological Engineering, Faculty of 1000, editorial board for Annuals Reviews of Cell and Developmental Biology, and Developmental Cell, and editor for Journal of Cell Science, Cell and Molecular Bioengineering, and Technology. He has been awarded the Presidential Early Career Award for Scientists and Engineers, the Angiogenesis Foundation Fellowship, the Office of Naval Research Young Investigator Award, and the Herbert W. Dickerman Award for Outstanding Contribution to Science. He received his Ph.D. from M.I.T., and M.D. from Harvard Medical School. He was the Skirkanich Professor of Innovation at the University of Pennsylvania and founding director of the Penn Center for Engineering Cells and Regeneration before his current appointment.