Epigenetic plasticity in tumor initiation and evolution
07 December 2016 12:00 to 13:00 EST
220 Mass. Avenue, Cambridge MA - USA
Speaker: Bradley E. Bernstein, MD, PhD Bernard and Mildred Kayden MGH Research Institute Chair Professor of Pathology, Harvard Medical School Institute Member, Broad Institute American Cancer Society Research Professor
Seminar Abstract: Our research aims to understand epigenetic mechanisms of tumor initiation and evolution, with a particular focus on brain tumors. Here I will present a model for glioma initiation by IDH mutation, in which DNA hyper-methylation causes chromosomal loops to mis-fold, leading to a loss of oncogene insulation. I will also discuss efforts to define the molecular circuits that enable glioblastoma stem cells to self-renew and evade therapeutic pressures. These studies exemplify ongoing projects in the lab that aim to bridge molecular epigenetic mechanisms with clinical context.
Entry instructions: There is no cost to attend the seminar. If you are interested in attending please contact Meghan Spencer. Please check in with security at the Novartis visitor's entrance of 220 Massachusetts Avenue and you will be directed to the location of the seminar.
Speaker | Bradley E. Bernstein, MD, PhD
Bradley Bernstein is the Bernard and Mildred Kayden Research Institute Chair and a Professor of Pathology at Massachusetts General Hospital, a Broad Institute Member, and an American Cancer Society Research Professor. Bernstein’s research focuses on epigenetics — changes in gene activity governed by influences outside the genes themselves — and specifically how modifications to the protein scaffold called chromatin contribute to mammalian development and human cancer. Bernstein received his B.S. from Yale University and his M.D. and Ph.D. from the University of Washington, before completing a residency in clinical pathology and postdoctoral research at Harvard University. Honors include the Paul Marks Prize for Cancer Research, an Early Career Scientist award from the Howard Hughes Medical Institute, and a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund.