Evolution of kinases over several billion years - Exploitation for novel cancer drugs
07 June 2017 12:00 to 13:00 EDT
220 Mass. Avenue, Cambridge MA - USA
Speaker: Dorothee Kern, Ph.D. Professor of Biochemistry and Howard Hughes Medical Institute Investigator Brandeis University
Seminar Abstract: Dorothee Kern will present how the characterization of the evolution of kinase dynamics over 1 billion years reveals the mechanism responsible Gleevec's selectivity, and how these lessons lead to the new vision to put protein dynamics at the heart of drug discovery. Dr. Kern will then shed light into the evolutionary origin of allosteric regulation and describe how this new knowledge is exploited for the development of allosteric inhibitors and activators in proof-of principle experiments. Ancestral Sequence Reconstruction combined with x-ray crystallography, NMR, fast kinetics and computation deliver detailed energy landscapes of the proteins.
Entry instructions: There is no cost to attend the seminar. If you are interested in attending please contact Meghan Spencer. Please check in with security at the Novartis visitor's entrance of 220 Massachusetts Avenue and you will be directed to the location of the seminar.
Speaker | Dorothee Kern, Ph.D.
Dorothee Kern is Professor of Biochemistry at Brandeis University and an Investigator of the Howard Hughes Medical Institute. She received her PhD at the Martin Luther University in Halle, Germany and then carried out her postdoctoral studies at UC Berkeley. She joined the faculty at Brandeis University in 1999. Her research group studies the dynamical nature of proteins with the goal to reveal the interplay between structure, dynamics and function. She has been a major contributor in the experimental characterization of protein dynamics during enzyme catalysis and signaling. She pursues a new vision of protein dynamics and allosteric networks at the heart of drug discovery. Recently Dr. Kern is reconstructing the evolution of proteins over billions of years. Dr. Kern is the recipient of the Pfizer Award in Enzyme Chemistry from the American Chemical Society, the National Lecturer of the Biophysical Society, the Dayhoff Award from the Biophysical Society, the Young Investigator Award of the International Association for Protein Structure Analysis and Proteomics and the Strage Award for Aspiring Young Science Faculty. Before her professional scientific carrier, she was captain of the German National Basketball team for many years and won an MVP award.