Multiplex genome engineering via CRISPR-Cas: new approaches and new challenges
02 November 2016 12:00 to 13:00 EDT
220 Mass. Avenue, Cambridge MA - USA
Speaker: Prashant Mali, Ph.D Assistant Professor, Department of Bioengineering University of California, San Diego
Seminar Abstract: The recent advent of RNA-guided effectors derived from clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems have dramatically transformed our ability to engineer the genomes of diverse organisms. As unique factors capable of co-localizing RNA, DNA, and protein, tools and techniques based on these are paving the way for unprecedented control over cellular organization, regulation, and behavior. Here I will describe some of our ongoing efforts towards engineering and scaling this platform with a focus on studying the human system.
Entry instructions: There is no cost to attend the seminar. If you are interested in attending please contact Meghan Spencer. Please check in with security at the Novartis visitor's entrance of 220 Massachusetts Avenue and you will be directed to the location of the seminar.
Speaker | Prashant Mali, Ph.D
Prashant Mali received a bachelor’s and master’s in Electrical Engineering from the Indian Institute of Technology Bombay and a doctorate in Biomedical Engineering at the Johns Hopkins University. During his postdoctoral fellowship in the Department of Genetics at the Harvard Medical School, he pioneered the development of the CRISPR-Cas systems for eukaryotic genome engineering. For his graduate work he received the Siebel Scholar Award in 2011, and in 2014 he received the Burroughs Wellcome Career Award at the Scientific Interface. Mali joined the University of California, San Diego faculty in 2014 as an assistant professor in the Department of Bioengineering. In 2016 he received the March of Dimes Basil O’Conner Scholar Award and the Kimmel Scholar Award.