A Stitch in Time: the Dynamics of Drug Tolerance and Treatment in TB and Beyond
14 September 2016 12:00 to 13:00 EDT
220 Mass. Avenue, Cambridge MA - USA
Speaker: Bree Aldridge, Assistant Professor, Tufts University Departments of Molecular Biology and Microbiology & Biomedical Engineering
Seminar Abstract: The variable course of tuberculosis disease and treatment response suggests that functionally heterogeneous populations of mycobacteria respond differently stress. Using a quantitative single-cell approach, we seek to quantitatively characterize mycobacterial subpopulations with distinct behaviors arising from asymmetric growth and division. We find stress response in mycobacteria is dependent on the timing of treatment, suggesting that drug regimens may be optimized through the dynamics of multidrug treatment.
Entry instructions: There is no cost to attend the seminar. If you are interested in attending please contact Meghan Somers. Please check in with security at the Novartis visitor's entrance of 220 Massachusetts Avenue and you will be directed to the location of the seminar.
Speaker | Bree Aldridge
Bree Aldridge is an engineer and a biologist and brings a quantitative approach to studying cell biology. At Tufts University, she has assembled a team of biologists, engineers, and mathematicians to investigate TB infection and drug response at single-cell resolution. She specializes in combining live-cell microscopy and mathematical modeling to create intuitive descriptions of complex cell biology. She earned double B.S. degrees in computer engineering and molecular and cellular biology and the University of Arizona (2002) before completing her PhD in biological engineering at MIT (2008). She brought her interdisciplinary perspective to TB and infectious diseases during her postdoctoral training at the Harvard School of Public Health.